BIO 320: Learning objectives for Exam 4
Chapter 16: Respiratory Physiology
● Understand the components of respiration:
○ Internal respiration;
○ External respiration.
● Understand the general organization of the res
...
BIO 320: Learning objectives for Exam 4
Chapter 16: Respiratory Physiology
● Understand the components of respiration:
○ Internal respiration;
○ External respiration.
● Understand the general organization of the respiratory system and the structural
and functional characteristics of each part:
○ Conducting zone;
○ Respiratory zone.
● Understand the pressure changes during breathing and their implications.
○ Boyle’s law: The pressure of a gas (fixed) is inversely proportional to its
volume.
● Understand the physical properties of the lungs, their cellular bases, and their
significance.
○ Compliance; the ease of a lung to expand under pressure
○ Elasticity; Lungs ability to regain original state after a stretch
○ Surface tension; low is easy to move & high is harder
■ Law of Laplace: The alveolar pressure is directly proportional to
the surface tension and inversely proportional to the radius of the
alveolus; The pressure increase, the radius decreases vice versa.
■ Surfactants: surface active agent
● Understand the mechanisms of breathing: inspiration & expiration
○ Muscles involved;diaphragm
○ Pressure changes;
● Understand the pulmonary functional tests
○ Lung volumes;
○ Lung capacities;
○ Restrictive versus obstructive lung disorders.
● Understand the Henry’s Law on the dissolution of gases in liquid.
● Understand the relationship between capillaries alveoli.
● Understand the measurements of blood Po2, it importan,t and how it differs from
hemoglobin saturation.
● Understand how partial pressures drive gas exchanges in the lung capillaries and
body capillaries.
● Understand the cellular mechanism that drives changes in pulmonary perfusion to
match ventilation.
● Understand the control of breathing:
○ Spinal motor neurons;
○ Rhythmicity center;
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○ Chemoreceptors;
○ Pulmonary receptors.
● Understand the respective effects of Pco2 and Po2 on ventilation.
● Understand the difference between the Po2 and the oxygen content of the blood.
● Understand the different forms of hemoglobin and their relation to O2.
● Understand the respective physiological relevance of:
○ Po2;
○ Percent oxyhemoglobin saturation;
○ Hemoglobin concentration.
● Understand oxygen loading versus unloading and the factors that affect each.
● Understand the factors that affect the affinity of hemoglobin for oxygen:
○ pH;
○ Temperature;
○ Carbon monoxide;
○ 2,3-diphosphoglyceric acid.
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