Acute Disorders of Brain Function
Question:
The brain contributes ____% of body weight and uses ____% of the body’s O2
consumption? 2,20
It doesn’t weigh much
It does consume high amount of O2 and blood flow (re
...
Acute Disorders of Brain Function
Question:
The brain contributes ____% of body weight and uses ____% of the body’s O2
consumption? 2,20
It doesn’t weigh much
It does consume high amount of O2 and blood flow (relative metabolic rate is
high)
o Very significant in regards to ICP- amt of O2 consumption and
therefore the amt of blood flow is high
Blood is a major component of ICP
Question:
Acute head injury produces high rates of both mortality and morbidity due to the
damage produced by the primary brain injury. False Secondary injury
Primary injury- injury of the actual trauma (ex. necrosis from stroke)
Secondary injury- body’s response to that injury and the effects of that
response
Really imp. in management. Can’t fix the primary injury (ex. dead tissue due
to stroke), but can fix the Secondary injury issues (ex. inflammatory response
to injury) typically.
Mechanisms of Brain Injury
The ultimate outcome of the neurons is the ability to function as normalability
to have ATP to function (goal: maintain O2 and perfusion of the cells)
o We maintain ATP through O2 (maintain cell membrane (Na+ K+ pump
and functioning of that cell))
o We maintain O2 through cell perfusion
Primary brain injury occurs as a direct result of the initial insult
Secondary injury refers to progressive damage resulting from the body’s
physiologic response to the initial insult
A critical factor in determining the neuronal cell fate after injury is the degree
of adenosine triphosphate (ATP) depletion
Mechanisms of Brain Injury (Cont.)
Ischemia and Hypoxia (la)
Ischemia- lack of perfusion to the tissue (big factor in the secondary response)-
causes lack of ATP / ATP depletion
Hypoxia- lack of oxygenation to the tissue
Hypoxemia- lack of O2 in the blood
Ischemia is a contributing factor either as the primary insult or as part of the
secondary response to injury
[Show More]