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Endocrine Lecture Notes

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• What is an endocrine hormone? How does it influence homeostasis vs. the nervous system. Acts more slowly than NS, NS acts quicker than the ES Has a longer term effect than NS, NS is moment to moment control Onset is ...

• What is an endocrine hormone? How does it influence homeostasis vs. the nervous system. Acts more slowly than NS, NS acts quicker than the ES Has a longer term effect than NS, NS is moment to moment control Onset is slower but it last for longer amount of time, NS onset is quicker but lasts for a short amount of time uses chemical signals, uses chemical and electrical signals • The endocrine system helps maintain homeostasis as well as the nervous system • nervous system uses electrical and chemical signals but the endocrine system only uses chemical messengers. • nervous system is quicker, moment to moment adjustments • endocrine system is slower to respond, has long term affect • Endocrine glands are ductless glands that secretes product into the blood indirectly • into interstitial fluid —> blood • nervous system will trump the endocrine system because it works fast, specific, short term moment to moment, endocrine is slower • How can we make a hormone work better • Increase the number of receptors • increase the amount of hormone secreted • Increase temperature • Increase affinity of receptor • how tightly the hormone binds to the receptors, longer action and stronger affect • decrease degradation (extend the 1/2 life) • Half-life • the amount of time required before only half of the original product remains • determined by the chemical class • the ability to store hormone ( aa can be stored, blood levels don't reflect what our bodies are doing) • lipid soluble hormones have a higher half life than water soluble hormones • blood levels reflect our body’s ability to make them • It is hydrophobic because it doesn't get into our water/urine and get excreted as easily. • Stimulation • Stimulating the release of hormones can be • Neural: • suckling is going to cause sensory information to synapse on the paraventricular nuclei to release oxytocin • pain for vasopressin, which synapses on cells on the supraoptic nuclei • Hormonal • prolactin inhibiting hormone is going to bind to prolactinocytes which decreases prolactin production • Dopamine is going to inhibit prolactin • hormone binding which will cause a response • Humeral: • Blood osmolarity, blood pressure, glucose ....................................................................CONTINUED...................................................

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