ASCP Hematology Review
Name the locations of active marrow in adults: - ANS - sternum, skull, ribs, pelvis, vertebrae
Where does hematopoiesis take place during the first 2 months of gestation? - ANS - yolk sac
Where
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ASCP Hematology Review
Name the locations of active marrow in adults: - ANS - sternum, skull, ribs, pelvis, vertebrae
Where does hematopoiesis take place during the first 2 months of gestation? - ANS - yolk sac
Where does the majority of hematopoiesis take place during the 2nd through 7th month of
gestation? - ANS - spleen
When does the bone marrow take over hematopoiesis? - ANS - after birth
What are the stages in order of the erythrocyte lineage? - ANS - (1)rubriblast, (2)prorubricyte,
(3)rubricyte, (4)metarubricyte, (5)reticulocyte, (6)erytrocyte
What are the stages in order of the granulocyte (neutrophil, eosinophil, basophil) lineage? - ANS
- (1)myeloblast, (2)promyelocyte, (3)myelocyte, (4)metamyelocyte, (5)band, (6)segmented
(7)eos/baso
What are the stages in order of the macrophage lineage? - ANS - (1)monoblast, (2)promonocyte,
(3)monocyte, (4)macrophage
What are the stages in order of the platelet lineage? - ANS - (1)megakaryoblast,
(2)promegakaryocyte, (3)megakaryocyte, (4)platelet
What are the stages in order of the lymphocyte lineage? - ANS - (1)lymphoblast,
(2)prolymphocyte, (3)lymphocyte
Which growth factors stimulate the erythrocyte lineage? - ANS - GM-CSF, EPO, IL-3
Which growth factors stimulate the granulocyte lineages? - ANS - GM-CSF, IL-3
Which growth factors stimulate the platelet lineage? - ANS - GM-CSF, IL-3, TPO
Which growth factors stimulate the lymphocyte lineage? - ANS - IL-2, IL-4, IL-6, IL-7
Which protein functions in the transport of Fe? - ANS - transferrin
What is the major storage form of Fe? - ANS - ferritin
What is the long-term (H20) insoluble Fe storage form called? - ANS - hemosiderin
Excess Iron is stored where? What does this cause? - ANS - tissues and body organs,
hemosiderosis, hemochromatosis
Porphyrias are attributed to? - ANS - excessive formation of porphrins due to blockages in any
enzymatic step in the heme synthesis pathway.
Red or port wine colored urine can be seen in which condition related to the build up of heme
precursors? - ANS - porphyria
Neuropsychiatirc symptoms are seen whe
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