ASCP-Chemistry section

ASCP-Chemistry section Aldosterone is released by the adrenal cortex upon stimulation by: A. Renin B. Angiotensinogen C. Angiotenisinogen I D. Angiotensinogen II - ✔✔D. Angiotensinogen II Clinical Assays for tumor ...

ASCP-Chemistry section Aldosterone is released by the adrenal cortex upon stimulation by: A. Renin B. Angiotensinogen C. Angiotenisinogen I D. Angiotensinogen II - ✔✔D. Angiotensinogen II Clinical Assays for tumor markers are most important for: A. screening for the presence of cancer B. monitoring the course of known cancer C. confirming the absence of disease D. identifying patients at risk for cancer - ✔✔B. Monitoring the course of known cancer Detection of which of the following substances is most useful to monitor the course of a patient with testicular cancer? A. alpha-fetoprotein B. carcinoembryonic antigen C. prolactin D. testosterone - ✔✔A. alpha-fetoprotein Increased concentrations of alpha-fetoprotein (AFP) in adults are most characteristically associated with: A. hepatocellular carcinoma B. alcoholic cirrhosis C. chronic active hepatitis D. multiple myeloma - ✔✔A. hepatocellular carcinoma Carcinoembryonic antigen (CEA) is most likely to be produced in a maignancy involving the: A. Brain B. Testes C. Bone D. Colon - ✔✔D. Colon Which of the following is useful in the detection an management of carcinoma of the prostate? A. total prostate-specific antigen B. prostatic acid phosphatase C. human chorionic gonadotropin D. alpha-fetoprotein - ✔✔A. total prostate-specific antigen Which of the following statements most correctly describes the utility of clinical laboratory assays for tumor markers? A. tumor markers are useful to screen asymptomatic patients for tumors B. tumor markers are highly specific C. tumor markers indicate the likelihood of an individual developing a tumor D. tumors are useful in tracking the efficacy of treatment - ✔✔D. tumors are useful in tracking the efficacy of treatment Cancer antigen 125 (CA 125) is a tumor marker associated with: A. breast carcinoma B. colon cancer C. lung cancer D. ovarian and endometrial carcinoma - ✔✔D. ovarian and endometrial carcinoma In addition to carcinoma of the prostate, elevated prostate-specific antigen (PSA) can occur due to: A. aspirin therapy B. exogenous steroid use C. benign prostatic hyperplasia D. statin therapy (cholesterol lowering drugs) - ✔✔C. benign prostatic hyperplasia A drug has a half-life of 6 hours. If a dose is given every 6 hours, a steady-state drug level would usually be achieved in: A. 3-5 hours B. 10-12 hours C. 24-42 hours D. 48-50 hours - ✔✔C. 24-42 hours The drug procainamide is prescribed to treat cardiac arrhythmia. What biologically active liver metabolite of procainamide is often measured simultaneously? A. phenobarbitol B. quinidine C. N-acetyl procainamide (NAPA) D. lidocaine - ✔✔C. N-acetyl procainamide (NAPA) Cocaine is metabolized to: A. carbamazepine B. codeine C. hydrocodone D. benzolecgonine - ✔✔D. benzolecgonine The metabolite 11-nor-tetrahydrocannabinol-9-COOH can be detected by immunoassay 3-5 days after a single use of: A. methamphetamine B. ccaine C. benzodiazepine D marijuana - ✔✔D. marijuana A 3-yr-old child was evaluated for abdominal pain and anorexia by a physician. A CBC revealed a hemoglobin of 9.8 g/dL (98 g/L) and basophilic stippling of the RBC's. The doctor should order further tests to check for poisoning from: A. arsenic B. iron C. mercury D. lead - ✔✔D. lead A carbonate salt used to control manic-depression disorders is: A. digoxin B. acetaminophen C. lithium D. phenytoin - ✔✔C. lithium An antiepileptic (or anticonvulsant) used to control seizure disorders is: A. digoxin B. acetaminophen C. lithium D. phenytoin - ✔✔D. phenytoin A drug that relaxes the smooth muscles of the bronchial passages is: A. acetaminophen B. lithium C. phenytoin D. theophylline - ✔✔D. theophylline A cardiac glycoside that is used in the treatment of congenital heart failure and arrythmias by increasing the force and velocity of myocardial contraction is: A. digoxin B. acetaminophen C. lithium D. phenytoin - ✔✔A. digoxin A salicylate level is performed to detect toxicity caused by ingestion of excess: A. acetaminophen B. aspirin C. ibuprofen D. psuedoephedrine - ✔✔B. aspirin Lithium therapy is widely used in the treatment of: A. hypertension B. hyperactivity C. aggression D. manic-depressive (bipolar) disorder - ✔✔D. manic-depressive (bipolar) disorder Testing for the diagnosis of lead poisoning should include: A. erythrocyte protoporphyrin (EPP) B. urine delta-aminolevulinic acid C. whole blood lead D. zinc protoporphyrin (ZPP) - ✔✔C. whole blood lead Blood received in the laboratory for blood gas analysis must meet which of the following requirements? A. on ice, thin fibrin strands only, no air bubbles B. on ice, no clots, fewer than 4 air bubbles C. on ice, no clots, no air bubbles D. room temperature, no clots, n